Will Alzheimer’s be cured by 2040?
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By cured, I mean an FDA-approved treatment that halts the deterioration in cognitive decline in at least 75% of cases

Dec 25, 10:46pm: Will Alzheimer’s be cured by 2040? → Will Alzheimer’s be cured by 2040?

  • Update 2025-06-04 (PST) (AI summary of creator comment): In the scenario where the FDA no longer exists, a treatment will be considered to meet the 'FDA-approved' requirement if it is allowed under a system where treatments are not explicitly forbidden. The treatment must still meet the efficacy criterion (halting cognitive decline in at least 75% of cases).

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What if the FDA no longer exists, and any treatment for anything not explicitly forbidden is allowed?

@ArmandodiMatteo I think I would count that as FDA-approved

July 2024: Donanemab Approved for Treatment of Early Alzheimer's Disease

Would early detection and treatment suffice, if it does not necessarily work after onset of substantial symptoms? Specifically, if a reliable early detection methodology arises, would you consider early-detected cases to be part of your total set from which you measure 75%?

New drug was just approved. https://www.nature.com/articles/d41586-023-00030-3

What if the cure isn't a drug?

@IsaacKing Any treatment counts.

Updated description

Does this have to be for all forms of Alzheimer's, regardless of cause? Broad efficacy in 80% of cases? What is the bar?

@EdwardKmett Edited the question. For all forms. At least 75% of cases

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